SAMe (S-Adenosyl-Methionine) was first discovered in 1952 and has been commercially available since the 1970's. SAMe is an important compound that occurs in every living cell and takes part in several biological reactions in the human body. The important physiological results of these reactions are the manufacture of joint cartilage and the maintenance of neural cell membrane function.

Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.

The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe also plays a role in the mediation of cell-to-cell communication.

The Only Time-Proven Form of SAMe:

SAM-e is the original form of SAM-e (pronounced "Sammy"), as developed in Italy and introduced to the United States. NatureMade® was one of the first supplement providers to market SAM-e domestically, and uses a form of SAM-e that has been time tested for over twenty years!

Manufacturing this product is extremely difficult, and it must be enteric coated for maximum effectiveness. NutraLife SAM-e must also be packaged in a cold form blister process. Our SAM-e is guaranteed 200 mg active S-Adenosyl-Methionine. If you find a product at a dramatically lower price than ours, and especially if that product is in a bottle, be suspicious!

SAM e is an important physiological agent synthesized by the body. SAMe is involved in over 40 biochemical reactions in the body. In fact, SAMe is found in every living organism.

Clinical studies indicate that supplementation of SAMe is capable of improving the structure and function of joint cartilage. SAMe has also been shown to actually increase cartilage formation. These effects can enhance joint health and mobility.

• Drug Interactions: Possible side effects when combined with MAOI and SSRI drugs.